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doi: 10.3389/fgene.2015.00148 61

Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)

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(2015) 2:e89

The importance of weight management in type 2 diabetes mellitus